Acute generalized exanthematous pustulosis
Acute generalized exanthematous pustulosis (AGEP) ແມ່ນປະຕິກິລິຍາທາງຜິວໜັງທີ່ຫາຍາກເຊິ່ງໃນ 90% ຂອງກໍລະນີແມ່ນກ່ຽວຂ້ອງກັບການບໍລິຫານຢາ. Acute generalized exanthematous pustulosis ມີລັກສະນະການລະລາຍຂອງຜິວໜັງຢ່າງກະທັນຫັນທີ່ປະກົດຂຶ້ນໂດຍສະເລ່ຍຫ້າມື້ຫຼັງຈາກເລີ່ມກິນຢາ. ການລະເບີດເຫຼົ່ານີ້ແມ່ນມີຕຸ່ມຜື່ນ, ເຊັ່ນ: ການລະເບີດຂອງຜິວຫນັງທີ່ມີສີຂາວຫຼືສີແດງຂະຫນາດນ້ອຍທີ່ປະກອບດ້ວຍວັດຖຸທີ່ມີເມກຫຼືເປັນໜອງ (ໜອງ). ບາດແຜຕາມຜິວໜັງປົກກະຕິຈະແກ້ໄຂພາຍໃນ 1-3 ມື້ຫຼັງຈາກຢຸດຢາທີ່ເປັນອັນຕະລາຍ.
☆ ໃນປີ 2022 Stiftung Warentest ຜົນໄດ້ຮັບຈາກເຢຍລະມັນ, ຄວາມພໍໃຈຂອງຜູ້ບໍລິໂພກກັບ ModelDerm ແມ່ນຕໍ່າກວ່າການປຶກສາຫາລືທາງດ້ານການປິ່ນປົວທາງໂທລະສັບເລັກນ້ອຍເທົ່ານັ້ນ.
ບາດແຜທີ່ແຜ່ລາມໄປດ້ວຍ erythema ແລະ pustules ປະກົດຂຶ້ນຢ່າງກະທັນຫັນ.
References
Acute generalized exanthematous pustulosis (AGEP) ເປັນປະຕິກິລິຢາຜິວໜັງ ທີ່ມີຈຸດດ່າງດຳ, ມີໜອງຢູ່ບໍລິເວນຜິວໜັງແດງ. ມັນມັກຈະເກີດຂື້ນເມື່ອຜູ້ໃດຜູ້ນຶ່ງກິນຢາບາງຊະນິດ, ເຊັ່ນຢາຕ້ານເຊື້ອ, ແລະແຜ່ລາມໄປທົ່ວຮ່າງກາຍຢ່າງໄວວາ. ຫຼັງຈາກຢຸດຢາທີ່ກະຕຸ້ນ, ອາການມັກຈະຫາຍໄປພາຍໃນສອງອາທິດ, ມັກຈະເຮັດໃຫ້ຜິວຫນັງບາງໆ. ເຖິງແມ່ນວ່າປົກກະຕິແລ້ວບໍ່ຮ້າຍແຮງແລະຈໍາກັດຢູ່ໃນຜິວຫນັງ, ກໍລະນີຮ້າຍແຮງສາມາດຖືກຈໍາແນກຄຽງຄູ່ກັບປະຕິກິລິຍາທາງຜິວຫນັງທີ່ຮ້າຍແຮງອື່ນໆເຊັ່ນ Stevens-Johnson syndrome ຫຼື toxic epidermal necrolysis. ການປິ່ນປົວແມ່ນການດູແລສະຫນັບສະຫນູນຕົ້ນຕໍ, ແລະການຄາດຄະເນສໍາລັບການແກ້ໄຂບັນຫາທີ່ສົມບູນຂອງພະຍາດແມ່ນປົກກະຕິດີ.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
ຜູ້ຊາຍອາຍຸ 76 ປີໄດ້ມາຫ້ອງສຸກເສີນຍ້ອນວ່າຜິວຫນັງຂອງລາວມີການປ່ຽນແປງໃນໄລຍະສອງມື້ທີ່ຜ່ານມາ. ທ່ານໝໍໄດ້ພົບເຫັນຈຸດສີແດງ ແລະບໍລິເວນທີ່ຍົກຂຶ້ນມາເທິງລຳຕົ້ນ ແລະແຂນ ແລະຂາຂອງລາວ. ເມື່ອເວລາຜ່ານໄປ, ແຜ່ນແພເຫຼົ່ານີ້ໄດ້ລວມເຂົ້າກັນ, ແລະລາວໄດ້ພັດທະນາເປັນຕຸ່ມຄ້າຍຄືສິວຢູ່ໃນພື້ນທີ່ສີແດງ. ການທົດສອບສະແດງໃຫ້ເຫັນຈໍານວນເມັດເລືອດຂາວສູງທີ່ມີຈໍານວນຫຼາຍຂອງປະເພດທີ່ເອີ້ນວ່າ neutrophils, ແລະເພີ່ມຂຶ້ນຂອງລະດັບ C-reactive protein .
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
